Newswise Feature Channel: Digestive Disorders

باحثو مايو كلينك يحددون بروتينات مرتبطة بمقاومة العلاج المناعي في سرطان القولون والمستقيم النقيلي

Mayo Clinic — Tue, 25 Mar 2025 21:20:57 EST

قد يساعد اكتشاف جديد أجراه باحثو مايو كلينك في تفسير سبب عدم استجابة العديد من مرضى سرطان القولون والمستقيم النقيلي للعلاج المناعي. ففي نتائج نُشرت في دورية Clinical Cancer Research، حدد الفريق البحثي بروتينات محددة، وهي "الفيبرونيكتين" و"أكتين العضلات الملساء"، داخل أنسجة سرطان القولون والمستقيم، ووجدوا أنها مرتبطة بمقاومة العلاج المناعي.

'Broken Heart Syndrome' Associated with Double the Risk of Rehospitalization for Wide Range of Conditions

American College of Physicians (ACP) — Mon, 24 Mar 2025 17:00:00 EST

Patients diagnosed with Takotsubo syndrome, or 'broken heart syndrome' face double the risk of rehospitalization for a wide range of conditions.

Study Identifies Gut Sensor That Propels Intestines To Move

Harvard Medical School — Mon, 24 Mar 2025 11:00:00 EST

Research in mice identifies protein responsible for regulating gut movement in response to pressure, exercise, and inflammation. The findings can inform precision-targeted treatments for intestinal inflammation and disorders of gut motility. The results add to a growing body of research showing the nervous and immune systems interact in various organs, including the brain, lungs, and skin.

Yale Surgeons to Present at International Surgical Oncology Conference

Yale Cancer Center/Smilow Cancer Hospital — Mon, 24 Mar 2025 10:55:32 EST

Yale Department of Surgery oncologists and trainees at Yale Cancer Center will present new findings at the Society of Surgical Oncology (SSO) Annual Meeting in Tampa, Fla., from March 27-29. The conference focuses on improving surgical cancer care for patients through educational sessions as well as oral and poster presentations for surgical oncologists, researchers, and patient advocates.

Epstein-Barr Virus Aggravates Ulcerative Colitis via Macrophage Pyroptosis: A New Therapeutic Target

Chinese Academy of Sciences — Mon, 24 Mar 2025 08:45:22 EST

A recent study has revealed how Epstein-Barr virus (EBV) intensifies ulcerative colitis (UC), a debilitating inflammatory bowel disease. Researchers discovered that EBV infection triggers macrophage pyroptosis--a form of inflammatory cell death--by accelerating glycolysis, a key metabolic pathway.

Mount Sinai-Led Team Identifies Cellular Mechanisms That May Lead to Onset of Inflammatory Bowel Disease

Mount Sinai Health System — Fri, 21 Mar 2025 14:00:00 EST

New study shows that dysfunction of protective immune cells in GI tract may contribute to onset of inflammation in Crohn's disease

Analysis of New Colorectal Cancer Immunotherapy Shows More Treatment Options

Cleveland Clinic — Thu, 20 Mar 2025 11:00:00 EST

A team of researchers from Cleveland Clinic Genomic Medicine share insights from an early set of 19,000 patients to receive immune checkpoint inhibitor treatments for colorectal cancer in the U.S. The report comes from the laboratory of Stephanie Schmit, PhD, MPH, and was published in JAMA Network Open. It serves as an opportunity to better understand how immune checkpoint inhibitor treatments, including PD-1 and PD-L1 inhibitors, work in a larger population that reflects real-world settings. Dr. Schmit collaborated with a team of researchers that included Moffitt Cancer Center.

Investigadores de Mayo Clinic identifican proteinas relacionadas con la resistencia a la inmunoterapia en el cancer colorrectal metastasico

Mayo Clinic — Wed, 19 Mar 2025 19:55:44 EST

Un descubrimiento realizado por investigadores de Mayo Clinic puede ayudar a explicar por que la inmunoterapia no ha sido util para muchos pacientes con cancer colorrectal metastasico. En los descubrimientos publicados en Clinical Cancer Research, el equipo identifico proteinas especificas -- fibronectina y actina del musculo liso -- dentro de los tejidos del cancer colorrectal que estan asociadas con la resistencia al tratamiento de inmunoterapia.

?Puede la dieta ayudar con la enfermedad intestinal inflamatoria?

Mayo Clinic — Wed, 19 Mar 2025 19:55:09 EST

La enfermedad inflamatoria intestinal (EII) es una inflamacion cronica del tracto digestivo. Incluye condiciones tales como colitis ulcerosa e enfermedad de Crohn. En esta alerta del experto, la Dra. Amanda Johnson, gastroenterologa en Mayo Clinic, explica la EII y si la dieta puede ayudar.

Can Diet Help with Inflammatory Bowel Disease?

Mayo Clinic — Wed, 19 Mar 2025 19:50:29 EST

Inflammatory bowel disease (IBD) is a chronic inflammation of the digestive tract. It includes conditions such as ulcerative colitis and Crohn's disease. In this expert alert, Amanda Johnson, M.D., a gastroenterologist at Mayo Clinic, helps explain IBD and whether diet can help.

Pesquisadores da Mayo Clinic identificam proteinas ligadas a resistencia a imunoterapia no cancer colorretal metastatico

Mayo Clinic — Wed, 19 Mar 2025 19:45:23 EST

Uma descoberta feita por pesquisadores da Mayo Clinic pode ajudar a explicar por que a imunoterapia nao tem sido util para muitos pacientes com cancer colorretal metastatico. Nas descobertas publicadas na Clinical Cancer Research, a equipe identificou proteinas especificas -- fibronectina e actina do musculo liso -- dentro dos tecidos do cancer colorretal que estao associados a resistencia ao tratamento imunoterapico.

Foods to Fortify

University of Miami — Wed, 19 Mar 2025 17:20:15 EST

Experts in nutrition science from across the University of Miami offer their thoughts on some of the best foods to help us ward off chronic disease.

هل يمكن أن يساعد النظام الغذائي في علاج داء الأمعاء الالتهابِي؟

Mayo Clinic — Wed, 19 Mar 2025 15:10:30 EST

داء الأمعاء الالتهابِي هو التهاب مزمن يصيب السبيل الهضمي ويشمل حالات مرضية مثل التهاب القولون التقرحي ومرض كرون. في تنبيه الخبير هذا، تساعد أماندا جونسون، دكتورة في الطب، طبيبة الجهاز الهضمي في مايو كلينك في شرح داء الأمعاء الالتهابِي وما إذا كان يمكن لاتباع نظام غذائي معين أن يساعد.

A dieta pode ajudar na doenca inflamatoria intestinal?

Mayo Clinic — Wed, 19 Mar 2025 15:00:40 EST

A doenca inflamatoria intestinal (DII) e uma inflamacao cronica do trato digestivo. Ela inclui condicoes como colite ulcerativa e doenca de Crohn. Neste alerta do especialista, a Dra. Amanda Johnson, gastroenterologista na Mayo Clinic, explica a DII e se a dieta pode ajudar.

Is It Irritable Bowel Syndrome or Something More Serious?

Mercy Medical Center — Tue, 18 Mar 2025 20:45:58 EST

Is It Irritable Bowel Syndrome or Something More Serious?

Northwestern Medicine Launches Clinical Program to Make Liver Transplants More Accessible for Patients with Stage 4 Colorectal Cancer

Northwestern Medicine — Tue, 18 Mar 2025 11:00:00 EST

Northwestern Medicine launches clinical program to make liver transplants more accessible for patients with stage 4 colorectal cancer

National Colorectal Cancer Awareness Month

George Washington University — Tue, 18 Mar 2025 10:35:12 EST

Probiotic Bacteria Regulate Gut Hormones

Federation of American Societies for Experimental Biology (FASEB) — Tue, 18 Mar 2025 09:45:33 EST

Researchers found that probiotic bacteria Limosilactobacillus reuteri can regulate gut hormones, revealing new insights into their potential health benefits. The study, published in The FASEB Journal, suggests probiotics may have systemic effects beyond digestion, impacting immune function and hormone secretion.

UTEP Researchers Develop Portable, Blood-Based Device that Detects Colon Cancer

University of Texas at El Paso — Thu, 13 Mar 2025 20:50:01 EST

Scientists at The University of Texas at El Paso are developing a less invasive portable device that would use blood samples to detect colorectal cancers. Their device is described in a new study published in the journal ACS Measurement Science Au.

Mayo Clinic Researchers Identify Proteins Linked to Immunotherapy Resistance in Metastatic Colorectal Cancer

Mayo Clinic — Thu, 13 Mar 2025 20:45:38 EST

A discovery by Mayo Clinic researchers may help explain why immunotherapy hasn't been helpful for many patients with metastatic colorectal cancer. In findings published in Clinical Cancer Research, the team identified specific proteins -- fibronectin and smooth muscle actin -- within colorectal cancer tissues that are associated with resistance to immunotherapy treatment.