Newswise Feature Channel: Stem Cells

Pausing Biological Clock Could Boost Lab-Produced Blood Stem Cells

Iowa State University — Mon, 09 Sep 2024 16:05:49 EST

An Iowa State University research team has discovered when and why inflammatory signaling affects the formation of blood stem cells in embryos, which will benefit efforts to develop lab-grown, patient-derived stem cell transfusions to treat blood disorders. The promising advancement in regenerative medicine could eliminate the need for bone marrow transplants.

UC Irvine, USC scientists begin research effort for damaged brain region treatments

University of California, Irvine — Thu, 05 Sep 2024 12:05:30 EST

With newly awarded funding from the National Science Foundation, researchers at the University of California, Irvine and the Keck School of Medicine of USC will seek to revolutionize the treatment of neurological diseases through intelligent biocomputing. The four-year, $2 million grant is part of NSF's Emerging Frontiers in Research and Innovation program, which funds cutting-edge science pushing the boundaries of human knowledge.

Breaking the link between obesity and atrial fibrillation with a new cellular target

University of Illinois Chicago — Wed, 04 Sep 2024 08:55:04 EST

Blocking oxidative stress enzyme prevents, even reverses, heart condition in lab models

Understanding and controlling the variables for stromal vascular fraction therapy

World Journal of Stem Cells — Mon, 26 Aug 2024 12:00:58 EST

In regenerative medicine, the isolation of mesenchymal stromal cells (MSCs) from the adipose tissue's stromal vascular fraction (SVF) is a critical area of study. Our review meticulously examines the isolation process of MSCs, starting wi

Bone marrow mesenchymal stem cells in treatment of peripheral nerve injury

World Journal of Stem Cells — Mon, 26 Aug 2024 12:00:56 EST

Peripheral nerve injury (PNI) is a common neurological disorder and complete functional recovery is difficult to achieve. In recent years, bone marrow mesenchymal stem cells (BMSCs) have emerged as ideal seed cells for PNI treatment due to

Pretreatment can alleviate programmed cell death in mesenchymal stem cells

World Journal of Stem Cells — Mon, 26 Aug 2024 12:00:52 EST

In this editorial, we delved into the article titled "Cellular preconditioning and mesenchymal stem cell ferroptosis." This groundbreaking study underscores a pivotal discovery: Ferroptosis, a type of programmed cell death, drastically

Understanding and controlling the variables for advanced cell therapy

World Journal of Stem Cells — Mon, 26 Aug 2024 12:00:51 EST

Potential plausible role of Wharton's jelly mesenchymal stem cells for diabetic bone regeneration

World Journal of Stem Cells — Mon, 26 Aug 2024 12:00:47 EST

This letter addresses the review titled "Wharton's jelly mesenchymal stem cells: Future regenerative medicine for clinical applications in mitigation of radiation injury". The review highlights the regenerative potential of Wharton'

Mesenchymal stem cells: A promising therapeutic avenue for non-alcoholic fatty liver disease

World Journal of Stem Cells — Mon, 26 Aug 2024 12:00:46 EST

Non-alcoholic fatty liver disease (NAFLD) is a pressing global health concern that is associated with metabolic syndrome and obesity. On the basis of the insights provided by Jiang et al, this editorial presents an exploration of the potent

Microvesicles derived from mesenchymal stem cells inhibit acute respiratory distress syndrome-related pulmonary fibrosis in mouse partly through hepatocyte growth factor

World Journal of Stem Cells — Mon, 26 Aug 2024 12:00:10 EST

BACKGROUNDPulmonary fibrosis is one of the main reasons for the high mortality rate among acute respiratory distress syndrome (ARDS) patients. Mesenchymal stromal cell-derived microvesicles (MSC-MVs) have been shown to exert antifibrotic ef

Searching old stem cells that stay young forever

University of Vienna — Mon, 19 Aug 2024 05:00:44 EST

The sea anemone Nematostella vectensis is potentially immortal. Using molecular genetic methods, developmental biologists led by Ulrich Technau from the University of Vienna have now identified possible candidates for multipotent stem cells in the sea anemone for the first time. These stem cells are regulated by evolutionary highly conserved genes, which in humans are usually only active in the formation of egg and sperm cells, but give ancient animal phyla such as cnidarians a high degree of regenerative capacity to even escape ageing. The results are currently being published in Science Advances and could also provide insights into the human ageing process in the future.

Zebrafish use surprising strategy to regrow spinal cord

Washington University in St. Louis — Thu, 15 Aug 2024 05:00:00 EST

Researchers at Washington University School of Medicine in St. Louis describe the dramatic changes within nerve cells that make regeneration possible. Such findings could inspire the development of new therapies for spinal cord injuries in people.

NK cells expressing interleukin-21 show promising antitumor activity in glioblastoma cells

University of Texas MD Anderson Cancer Center — Mon, 12 Aug 2024 11:00:00 EST

Natural killer (NK) cells engineered to express interleukin-21 (IL-21) demonstrated sustained antitumor activity against glioblastoma stem cell-like cells (GSCs) both in vitro and in vivo, according to new research from The University of Texas MD Anderson Cancer Center.

Mechanistic basis of lineage restriction

VectorBuilder Inc — Mon, 12 Aug 2024 10:00:00 EST

Groundbreaking Study Solves Mystery of Multicellularity

VectorBuilder Inc — Mon, 12 Aug 2024 10:00:00 EST

A team of researchers from multiple institutions including the University of Chicago and VectorBuilder, has made a significant breakthrough in the understanding of lineage restriction, a biological phenomenon foundational to multicellular lifeforms as it secures the functional identities of the myriad cell types in the body.

Potential New Approach to Enhancing Stem-Cell Transplants

Albert Einstein College of Medicine — Thu, 08 Aug 2024 14:00:00 EST

A discovery by a three-member Albert Einstein College of Medicine research team may boost the effectiveness of stem-cell transplants, commonly used for patients with cancer, blood disorders, or autoimmune diseases caused by defective stem cells, which produce all the body's different blood cells.

A First for Cedars-Sinai's Fourth Space Launch

Cedars-Sinai — Fri, 02 Aug 2024 10:05:44 EST

Cedars-Sinai is planning its first-ever attempt to produce stem cells in space and its fourth launch of stem cell experiments to the International Space Station. The NASA-funded launch is scheduled for Aug. 3 at 11 a.m. EDT/8 a.m. PDT.

MSK Research Highlights, July 31, 2024

Memorial Sloan Kettering Cancer Center — Wed, 31 Jul 2024 09:05:28 EST

New research from Memorial Sloan Kettering Cancer Center (MSK) showed giving chemotherapy shortly after a stem cell or bone marrow transplant from a less than perfectly matched donor greatly reduces the chances that the patient will develop graft-versus-host disease (GVHD); and sheds new light on cell state changes in prostate cancer.

Recent insights and advances in treatment and management show promise in stemming the growing prevalence of diabetes

University of California, Los Angeles (UCLA), Health Sciences — Fri, 26 Jul 2024 15:05:40 EST

A new paper surveying advances in diabetes pathogenesis and treatment explores the complex factors contributing to the onset and progression of the disease, suggesting that an understanding of these dynamics is key to developing targeted interventions to reduce the risk of developing diabetes and managing its complications.

Additional comments on extracellular vesicles derived from mesenchymal stem cells mediate extracellular matrix remodeling in osteoarthritis

World Journal of Stem Cells — Fri, 26 Jul 2024 12:00:48 EST

Recently, we read an article published by the Yang et al. The results of this study indicated that engineered exosomes loaded with microRNA-29a (miR-29a) alleviate knee inflammation and maintain extracellular matrix stability in Sprague Daw